A Study to Evaluate Safety of Multiple Dose of ASP0456 in Healthy Subjects

Inclusion Criteria: * Healthy, as judged by the investigator/subinvestigator based on the results of physical examination and all tests obtained * Body weight (at screening); * female ≥40.0 kg,\<70.0 kg * male ≥50.0 kg,\<80.0 kg * BMI(at screening): ≥17.6,\<26.4 Exclusion Criteria: * Received any investigational drugs in other clinical or post-marketing studies within 120 days before the study * Donated 400 mL of whole blood within 90 days, 200 mL of whole blood within 30 days, or blood components within 14 days before the study * Received medication within 10 days before dose is administered or is scheduled to receive medication * History of drug allergies * Upper (e.g. nausea, vomiting, stomachache) and lower (e.g. abdominal pain) gastrointestinal disease within 7 days before the study * Concurrent or previous hepatic disease * Concurrent or previous heart disease * Concurrent or previous renal disease