The purpose of this study is to examine the influence of premedication drugs Atropin, Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac output in term and preterm newborn infants. Two different protocols of premedication are compared.
Influence of the following procedures will be examined: * Application of Atropin * Application of Fentanyl * Application of Mivacurium * possible desaturation and / or bradycardia during intubation attempts * restoration of arterial oxygen saturation and / or heart rate after succesful intubation We aim to examine the change of the following parameters by the use of electrical cardiometry: * stroke volume * cardiac output We compare two different premedication protocols and we evaluate the impact of these protocol on the time needed for intubation and on intubation difficulties .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
24
1. Atropin 10µg/kg 2. Mivacurium 200µg/kg immediately followed by 3. Fentanyl 2µg/kg
1. Atropin 10µg/kg 2. Fentanyl 2µg/kg, repeat max. two times 3. Mivacurium 200µg/kg
University Medical Center
Ulm, Baden-Wurttemberg, Germany
Change of cerebral tissue oxygen saturation during premedication and intubation
A baseline value of cerebral tissue oxygen saturation before first application of premedication drugs is determined. Change of cerebral tissue oxygen saturation is defined as area under this threshold from first drug application until recovery.
Time frame: from 1 minute before first study drug until 10 minutes after end of procedure
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