The purpose of this study is to examine the influence medical or surgical treatment for patent ductus arteriosus in preterm infants on cerebral and renal tissue oxygenation and on cardiac output.
In this observational trial the investigators want to examine whether clinical or echocardiographic parameters of patent ductus arteriosus are related to * cerebral tissue oxygen saturation, total hemoglobin, fractional tissue oxygen extraction and HbD * renal tissue oxygen saturation, total hemoglobin, fractional tissue oxygen extraction and HbD as measured by near infrared spectroscopy and to * stroke volume * cardiac output as measured by electrical cardiometry. The investigators want to examine the impact of surgical and medical treatment for patent ductus on these parameters. The investigators want to compare the change of these parameters between responders to medical treatment and nonresponders.
Study Type
OBSERVATIONAL
Enrollment
35
3 doses of 0,2mg/kg every 12h (first week of life) or every 8h (after first week of life)
In nonresponders to medical treatment with persistent hemodynamically relevant patent ductus arteriosus surgical ligation is performed.
3 doses every 24h; first dose 10mg/kg, second and third dose 5mg/kg
University Medical Center
Ulm, Baden-Wurttemberg, Germany
Change of cerebral tissue oxygen saturation during treatment for patent ductus arteriosus
Time frame: from 10 minutes before start of infusion until 4 hours after end of transfusion
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