Study of the Aerosol Deposition With Vented and Unvented Jet Nebulizer in Healthy Subjets

Cliniques universitaires Saint-Luc- Université Catholique de Louvain7 enrolled

Overview

Open-vent jet nebulizers are frequently used to promote drug lung deposition but their clinical efficacy and indications are not clear. Our study aimed to compare inhaled mass, and lung deposition of amikacin by using a jet nebulizer (Sidestream) under two different configurations: vented and unvented coupled to a 110 ml corrugated piece of tubing.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Aerosol Drug Therapy

Interventions

Vented and Unvented Jet NebulizerDEVICE

Nebulizers used with 500mg aminoglycosides in 4ml until One minute after the sputerring point.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy Volunteers between 18 and 60 years old Exclusion Criteria: * Smokers * Pathological spirometry * History of treatment with aminoglygosides 1 month prior the study * Known allergy to aminoglycosydes * Any lung pathology or history of lung surgery

Locations (1)

Cliniques Universitaires Saint-Luc

Brussels, Brussels Capital, Belgium

RECRUITING

Outcomes

Primary Outcomes

Amikacin Urinatory excretion

Time frame: Each miction during 24 hours

Central Contacts

Laurent NP Pitance, PT

CONTACT

+3227645711 laurent.pitance@uclouvain.be

Giusepe Liistro, MD

CONTACT

+3227642843 Giusepe.liistro@uclouvain.be

Data from ClinicalTrials.gov

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