Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. The investigators therefore investigate the effect of Escitalopram as a perioperative analgesic.
Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. Patients with high pain catastrophizing are mentally vulnerable and may be sensitive to the effects of Escitalopram. We therefore investigate the effect of Escitalopram as a perioperative analgesic in this group of patients where the pain problem is pronounced.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
120
Tables with Escitalopram (10 mg), 1 tablet a day for 7 days, starting on the day of surgery
Placebo tablets, 1 tablet a day for 7 days, starting on the day of surgery
Gentofte Hospital
Gentofte Municipality, Hellerup, Denmark
Regionshospitalet Holstebro
Holstebro, Holstebro, Denmark
Vejle Sygehus
Vejle, Vejle, Denmark
Pain
Pain during walking at 24 hour after surgery
Time frame: At 24 hour
Pain
Pain at rest and during walking the first week after TKA
Time frame: 1 week
Cumulated pain scores
Cumulated pain scores for pain the first week after TKA
Time frame: 1 week
Amount of rescue analgesic
Amount of rescue analgesic the first week after TKA
Time frame: 1 week
Side effects
Side effects the first week after TKA
Time frame: 1 week
anxiety, depression, and sleep quality
Anxiety, depression, and sleep quality - questionnaire - the first week after TKA
Time frame: 1 week
Escitalopram level in blood-sample
Escitalopram level in blood-sample 48 hours after surgery
Time frame: 48 hours
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