Dronaderone to Prevent Recurrent Implantable Cardioverter Defibrillator (ICD) Shocks

Rabin Medical Center20 enrolled

Overview

Recurrent ICD shocks are a serious problem in pts with ICD. Treatment failure with other antiarrhythmics and ablation are common. Dronedarone is a new antiarrhythmic drug with ion channel properties similar to amiodarone. Several case reports have shown promising results with Dronedarone for this patient population.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

ICD ICD SHOCKS DRONEDARONE

Interventions

Dronedarone armDRUG

PO Dronedarone 400 mg BID

DronedaroneDRUG

Dronedarone PO 400 MG BID

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Recurernt ICD shocks depite other antiarrhythmic drug therapy Exclusion Criteria: * CHF NYHA IV OR DECMPENSATED III * PERMANENT AF * LIVER DYSFUNCION * CR CLEARANCE \<30

Outcomes

Primary Outcomes

Number of ICD shocks due to VT in the 6 months period after starting Dronedarone

Time frame: 1 year

Data from ClinicalTrials.gov

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