Open-label Study to Compare Hospitalization Rates of Schizophrenic Patients Treated With Oral Antipsychotics Versus IM Depot Aripiprazole

Inclusion Criteria: * Subjects who are able to provide written informed consent. If the IRB requires consent by a legally acceptable representative in addition to the subject, all required consents must be obtained prior to any protocol-required procedure. * Male and female subjects 18 to 65 years of age, inclusive. * Current diagnosis of schizophrenia as defined by DSM-IV-TR criteria and a history of the illness for at least 1 year (12 months). * Subjects who in the investigator's judgment would benefit from extended treatment with a long-acting injectable formulation. * Subjects who have at least 1 inpatient psychiatric hospitalization in the 4 years (48 months) prior to screening, but have been managed as outpatients for the 4 weeks prior entering the study. * Subjects must have been on oral antipsychotic treatment for the full 7 months prior to the screening phase. * Subjects who have shown response to previous antipsychotic treatment. * Subjects who understand the nature of the trial and are able to follow the protocol requirements. Exclusion Criteria: * Prisoners or subjects who are compulsorily detained (involuntarily incarcerated), or have been incarcerated in the past 7 months for any reason must not be enrolled into this trial. * Subjects who may require potent CYP2D6 or CYP3A4 inhibitors or CYP3A4 inducers during the trial. * Any subject who requires or may need any other antipsychotic medications during the course of the trial, other than allowed rescue medication. * Subjects who are known to be allergic, intolerant, or unresponsive to prior treatment with aripiprazole or other quinolinones. * Subjects with a history of hypersensitivity to antipsychotic agents. * Subjects deemed intolerant of receiving injectable treatment. * Subjects who have received electroconvulsive therapy within the last 7 months prior to screening. * Subjects with a history of neuroleptic malignant syndrome or clinically significant tardive dyskinesia as assessed by the investigator. * Subjects with a current DSM-IV-TR diagnosis other than schizophrenia, including schizoaffective disorder, major depressive disorder, bipolar disorder, delirium, dementia, amnestic or other cognitive disorders. Also, subjects with borderline, paranoid, histrionic, schizotypal, schizoid, or antisocial personality disorder. * Subjects requiring hospitalization for any psychiatric reason during the 4 weeks prior to signing the ICF or during the screening period. * Subjects without at least 1 inpatient psychiatric hospitalization in the last 4 years (48 months) prior to screening. * Subjects who have met DSM-IV-TR criteria for any significant substance use disorder within 3 months prior to screening. * Subjects who are considered treatment-resistant to antipsychotic medication other than clozapine. * Treatment with long-acting injectable antipsychotics in which the last dose was within 7 months prior to screening. * Subjects who have not been treated with oral antipsychotics for 7 months prior to screening. * Subjects who have a significant risk of committing suicide * Subjects who have a history or evidence of a medical condition that would expose them to an undue risk of a significant adverse event or interfere with assessments of safety or efficacy during the course of the trial. * Females who are pregnant or lactating, sexually active males and females who will not commit to utilizing birth control during the trial and for up to 180 days following the trial. * Abnormal laboratory or physical examination results indicating a condition which may interfere with the results of the study or pose a safety risk to the subject. * Subjects who have previously enrolled in an aripiprazole IM depot clinical study, except for subjects entering this trial from the Canadian 31-11-284 trial. * Subjects who have participated in any clinical trial with an investigational agent within the past 30 days.