NEMO1:NEonatal Seizure Using Medication Off-patent

Inclusion Criteria:- * Male or female term baby with gestational age of 37-43 weeks and postnatal age \<48 hours * One or more of the following: * APGAR score \< 5 at 5 mins. * Umbilical cord or first arterial blood sample pH \< 7.1 or base deficit \>16 mmol/L. * Postnatal resuscitation still required 10 minutes after birth * Clinically evolving encephalopathy * Received one dose of standard anticonvulsive therapy (phenobarbitone,20mg/kg) for clinical or electrographic seizures. * EEG: equal to or more than 3 min cumulative seizures, or 2 or more seizures of \>30 sec duration over 2 hr period within first 48 hr of life * Written informed consent of parent or guardian. * EEG monitoring has commenced within the first 48 hours of birth. Exclusion Criteria: * Suspected or confirmed brain malformation, inborn error of metabolism,genetic syndrome, or major congenial malformation * Congenital (in utero) infection (TORCH). * Babies who have received diuretics such as furosemide or bumetanide in routine clinical management within the last 24 hours. * Total serum bilirubin \> 15 mg/dl (255 micromol/l) at inclusion. * On any other anticonvulsive medication other than phenobarbitone or bolus of midazolam / pentobarbitone for intubation. * Anuria/renal failure defined as serum creatinine \> 200 micromol/l. * Severe electrolyte depletion (Na \<120 mmol/L, K \<3.0 mmol/L)