Allogeneic stem cell transplantation is potential curative therapy for adult lymphoid malignancies. Based on our previous study, the condition with iv-busulfan (iv-BU) and cyclophosphamide (CTX) is feasible with low toxicity and transplantation mortality and long-term survival is comparable to most data reported with slightly higher relapse rate particularly for patients in CR2. In this study, the investigators aim to further improve the conditioning with Fludarabine + iv-BU and to use CTX after stem cell transfusion as consolidation for lymphoid malignancies and graft-versus-host disease (GVHD) prophylaxis.
Patients with adult lymphoid malignancies received conditioning with Fludarabine + iv-BU. The GVHD was consisting of D+3 and D+4 CTX after stem cell transfusion. CSA will be added for all patients after D+5.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
31
Fludarabine at 30mg/m2 daily followed by iv-Busulfan at 3.2mg/kg daily for a total of 4 days from Day-6 to -3 and cyclophosphamide as 60mg/kg daily for 2 days on Day +3 and +4, CSA 3mg/kg starting after D+5.
Blood and Marrow Transplantation Center, Rui Jin Hospital
Shanghai, Shanghai Municipality, China
acute graft versus host disease (GVHD)
d100 incidence of acute GVHD, grade II-IV or grade III-IV
Time frame: day 100
chronic GVHD
3-year incidence of chronic GVHD and extensive cGVHD
Time frame: 3 years
non-relapse mortality (NRM)
estimated 3-year NRM after transplantation (death not due to relapse disease)
Time frame: 3 years
cumulated incidence of relapse (CIR)
estimated 3-year CIR after transplantation
Time frame: 3 years
event-free survival (EFS)
estimated 3-year EFS estimated 3-year EFS after transplantation
Time frame: 3 years
overall survival (OS)
estimated 3-year OS after transplantation
Time frame: 3 years
GVHD-free, relapse-free survival (GRFS)
estimated 3-year survival for patients without relapse, without III-IV aGVHD and without cGVHD required systemic treatment
Time frame: 3 years
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