Cabazitaxel in Patients With Urothelial Carcinoma Who Have Disease Progression Following Platinum-Based Chemotherapy

Inclusion Criteria: * Patients must have histologically confirmed urothelial carcinoma * Patients must have measurable disease * Patients must have been previously treated with a platinum-based regimen, either in the neoadjuvant, adjuvant or first line setting * Patients can have had disease progression while on platinum chemotherapy, or progression within 12 months of completion of therapy * At least 4 weeks must have passed since the last dose of previous chemotherapy * Age \> 18 years * ECOG performance status \< 2 (Karnofsky \> 60%) * Life expectancy of greater than 6 months * Patients must have adequate organ and marrow function as defined below: * absolute neutrophil count \> 1,500/mcL * hemoglobin \> 9.0 g/dl * platelets \> 100,000/mm3 * total bilirubin \< normal institutional limits (ULN) * AST(SGOT)/ALT(SGPT) \< 1.5 X institutional upper limit of normal * creatinine \<1.5 x ULN OR creatinine clearance measured \> 50 mL/min/1.73 m2for patients with creatinine levels above institutional normal or calculated clearance \< 60 by 24 hour urine * Peripheral neuropathy: must be \< grade 1 * Women of childbearing potential must have a negative pregnancy test, and patients must use adequate contraception during study and for 3 months thereafter * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Patients with any component of small cell carcinoma * Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier * Patients who are receiving any other investigational agents * Patients with known brain metastases * History of allergic reactions attributed to compounds of similar chemical or biologic composition to taxane chemotherapy * Patients with a history of severe hypersensitivity reaction to Cabazitaxel or other drugs formulated with polysorbate 80 * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Pregnant and breastfeeding women * HIV-positive patients on combination antiretroviral therapy * Patients who have previously been treated with taxane regimens for bladder cancer or other malignancies * Patients who have had more than one platinum based chemotherapy regimen * Patients whose cancer has progressed more than 12 months following abstinence from platinum based chemotherapy can be included on study at the discretion of the investigator, however should first be considered for platinum re-challenge