The etiology of bladder pain syndrome is unknown. Therefore the management is directed to pain relief, as bladder pain is believed to drive both voiding frequency and nocturia. Botulinum toxin A has been shown to decrease noxious input. Several studies showed efficacy of botox for treatment of painful bladder. The aim of this study is to evaluate the efficacy of Botulinum toxin in patients who are suffering bladder pain syndrome with Hunner lesions during cystoscopy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Bladder intratrigonal injection of botulinum toxin during cystoscopy under general anesthesia
cystoscopy under general anesthesia
Urology department of moscow state university of medicine and dentistry
Moscow, Russia
RECRUITINGChange from baseline in pain intensity
Pain intensity is scored using a 10-point visual analog scale and change from baseline is observed
Time frame: 1 week followed by 1, 3, and 6 months after BoNTA injection
Change from baseline of intensity of bladder bother symptoms
O'Leary-Sant score was used to assess symptoms and problems.
Time frame: within 1 week, at 3 months and 6 months
Change from baseline of quality of life
Quality of life (QoL) was evaluated using question 8 of the International Prostate Symptoms Score.
Time frame: within 1 week, at 3 months and 6 months
Postvoid residual urine volume
uroflowmetry with residual urine measurement
Time frame: within 1 week, at 3months and 6 months after BoNTA injection
Upper urinary tract retention
Kidney ultrasound investigation
Time frame: 1 week, 3 months and 6 months after BoNTA injection
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