Effects of Treatment of Ascites by the ALFApump System on Renal and Circulatory Function

Inclusion Criteria: 1. Patients \> 18 years of age 2. Cirrhosis of the liver defined by histological and/or clinical, analytical and radiological criteria. 3. Presenting refractory or recurrent ascites, requiring 2 or more evacuation paracentesis procedures over the last 3 months. 4. Written informed consent 5. Ability to comply with study procedures and ability to operate the device 6. Women of childbearing age should use adequate contraceptives Exclusion Criteria: 1. Digestive haemorrhage over the last 7 days (these patients can be included once the 7-day period has gone by). 2. Kidney failure defined as serum creatinine higher than or equal to 2 mg/dl. 3. Serum bilirubin greater than 5 mg/dl. 4. Severe coagulopathy defined as platelet count of less than 40,000 or prothrombin time of less than 40%. 5. Recurring bacterial peritonitis, defined as 2 or more episodes over the last 6 months. 6. Recurring urinary infections, defined as 2 or more episodes over the last 6 months. 7. Clinical evidence of loculated ascites. 8. Advanced hepatocarcinoma, defined as one which exceeds Milan criteria. 9. Previous liver transplant. 10. Obstructive uropathy or any bladder anomaly which might contraindicate implantation of the device. 11. Pregnancy 12. Patients being in another clinical study that did not reach primary endpoint yet