Endothelial Function, Arterial Stiffness and Components

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins32 enrolled

Overview

Specific Aim: Compare the endothelial function, arterial stiffness and components of metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy sibling controls. Plan: A cross sectional study comparing ALL survivors to sibling controls including measures of endothelial function and arterial stiffness obtained form a peripheral artery tonometry device, height, weight, waist circumference, fasting lipid, glucose and insulin.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Lymphoblastic Leukemia

Eligibility

Sex: ALLMin age: 8 YearsMax age: 28 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Survivor: Inclusion 1. Ages 8-28 (8 is chosen as lower age limit because developmental understanding will allow survivor to follow instructions for procedures, 28 is chosen as upper limit to include age ranges seen for treatment in the pediatric program) 2. Off therapy for at least 6 months and not more than 10 years (6 months Inclusion 1. Biological sibling 2. Ages 8-28 (when more than one sibling is available the one closest in age will be chosen.)) Exclusion Criteria: 1. Uncontrolled medical conditions that could interfere with participation or interpretation of results 2. History of relapsed ALL or history of bone marrow transplantation

Locations (2)

Johns Hopkins Hospital

Baltimore, Maryland, United States

Sidney Kimmel Comprehensive Cancer Center

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

measure of endothelial

Time frame: at enrollment

Data from ClinicalTrials.gov

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