Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine

University of Lausanne Hospitals52 enrolled

Overview

The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine and ketamine in the perioperative period of abdominal surgery.

Optimal postoperative pain management facilitates rehabilitation immediately after abdominal surgery. Multiple studies have demonstrated that successful postoperative analgesia also reduces perioperative complications and improves patient comfort, thereby providing many benefits for the patient. In acute postoperative pain management intravenous lidocaine and/or ketamine have been advocated because of their morphine-sparing effect.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain

Interventions

Lidocaine,DRUG

Lidocaine group received an IV bolus of 1.5 mg.kg-1 followed by a continuous infusion of 2 mg.kg-1.h-1 intraoperative and 1.33 mg.kg-1.h-1 for 48 h postoperative.

KetamineDRUG

Ketamine group received a bolus of 0.5 mg.kg-1, then 0.25 mg.kg-1.h-1 followed by 0.1 mg.kg-1.h-1 for the first 24 h, then 0.05 mg.kg-1.h-1 for the next 24 h.

association ketamine-lidocaineDRUG

Ketamine-lidocaine group received a bolus of 1.5 mg.kg-1 of lidocaine and 0.5 mg.kg-1 of ketamine, a continuous infusion of 1.3 mg.kg-1.h-1 of lidocaine and 0.17 mg.kg-1.h-1 of ketamine was delivered followed by 0.9 mg.kg-1 of lidocaine with 0.08 mg.kg-1.h-1 of ketamine during 48 h, the dose of ketamine being reduced to 0.04 mg.kg-1.h-1 after the first 24 hours.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * abdominal surgery by laparotomy Exclusion Criteria: * laparoscopy * history of chronic pain * opioid self-administration * psychiatric disorders * difficulties with communication * renal or hepatic dysfunction * ASA physical status \> 3

Locations (1)

University Hospital Center and University

Lausanne, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

Cumulative morphine consumption

Cumulative morphine consumption over 48 hours postoperatively

Time frame: 48 hours

Secondary Outcomes

Pain scores

Pain scores at rest and movement

Time frame: 48 hours

Mechanical hyperalgesia

Mechanical hyperalgesia using pressure algometry

Time frame: 48 hours

Occurrence of side effects

Occurrence of side effects: sedation, nausea, vomiting, itching, nightmares

Time frame: 48 hours

Data from ClinicalTrials.gov

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