Topiramate Bioequivalence Study Brazil - Fast

Inclusion Criteria: * Male * Age between 18 and 50 years * Body mass index between 19 and 28,5 kg/m2 * Good health conditions * Capable to understand the study's nature and aim, including risks and adverse effects and with intention to cooperate with the researcher and to act in compliance with requirements of the assay, this will be confirmed by the informed consent's signature Exclusion Criteria: * The volunteer has a known hypersensitivity to the study drug (topiramate) or to compounds chemically related * History or presence of hepatic or gastrointestinal illnesses, or other condition that interferes over the drug's absorption, distribution, excretion or metabolism * History of hepatic, renal, pulmonary, gastrointestinal, epileptic, hematologic or psychiatric illness; hypo or hypertension of any etiologic that needs pharmacologic treatment; has history or had myocardial infarction, angina and/or heart insufficiency * Non-recommended electrocardiographic findings, according to investigator criteria, for the study's participation * The results of the laboratory exams are out of the values considered as normal according to this protocol's rules, unless that they are considered as clinically irrelevant by the investigator * The volunteer is a smoker * The volunteer ingests more than 5 cups of coffee or tea a day * Has history of alcohol or drugs abuse * Use any regular drug within the 02 weeks that preceded the beginning of the treatment and the assessment date, or employed any drug that can interfere with the study within one week * The volunteer was hospitalized for any reason within 08 weeks of the beginning of this study's first period of treatment and the assessment date * Treatment within the 03 previous months of the study with any known drug that presents toxic potential for important organs * The volunteer participated in any experimental study or ingested any experimental drug within the 06 months that precede the beginning of this study and the assessment date * The volunteer donated or lost 450 mL or more of blood within the 03 months that preceded to the study initiation or donated more than 1500 mL within 12 months between the beginning of the study and the assessment date * Consume of inductive drugs and/or enzymatic inhibitors (CYP450 - hepatic), that are toxic for the organism or presenting long half-life's elimination within the 04 weeks that precede the study's initiation * Consume of alcohol in 48 hours antecedents to the admission to the study and along the study period * Consume of food or beverages containing grapefruit (grapefruit) within 24 hours preceding each study period * History of serious adverse reactions or hypersensitivity to any drug * The volunteer has any condition that obstructs his participation in the study according the investigator's judgement