Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients With Refractory Primary Biliary Cirrhosis

Inclusion Criteria: * There must be at least two of the following: a concentration in serum of AMAs at titres of 1:40 or higher; an unexplained rise in the amount of alkaline phosphatase of at least 1•5 times the upper limit of normal for more than 24 weeks; and compatible liver histological findings, specifically non-suppurative cholangitis and interlobular bile duct injury. * Incomplete response to UDCA at 13-15 mg/kg/day, Criteria for the group of complete responders is including: concentrations of alkaline phosphatase less than three times the upper limit of normal, aspartate aminotransferase less than twice the upper limit of normal, and bilirubin less than 17 μmol/L;and normalisation of abnormal concentrations of bilirubin, albumin, or both. * Liver pathological staging in 2 or3, Histological staging is based on Ludwig's and Scheuer's classifications Exclusion Criteria: * Patients are receiving any other investigational agents within 4 weeks of study entry * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection (defined as invasive fungal infection and progressive CMV viremia), symptomatic congestive heart failure (NYH class III and IV), unstable angina pectoris, or cardiac arrhythmia * In pregnancy or lactation * Psychiatric illness or mental deficiency making compliance with treatment or informed consent impossible * HCVpositive ，HBSAg positive or with other liver diseases * Combined with other autoimmune disease * Expected survival time is less than one year * Decompensation of liver function（Child B or C） * Have a history of allergy or Allergic constitution