Ex Vivo Evaluation of the Interest of the Association of Platinum With a Molecule BH3-mimetic ABT-737 in Samples of Ovarian Tumors

Centre Francois Baclesse36 enrolled

Overview

The aim of the study is to quantify the ex vivo induction of apoptosis by ABT-737 + association platinum in samples exposed and demonstrate the value of this combination compared to the agents used alone.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ovarian Cancer

Interventions

culture ex vivo with exposure to different therapeutic agents alone or in combination.OTHER

When tumor resection, tumor specimens of ovarian cancer will be made towards a culture ex vivo with exposure to different therapeutic agents alone or in combination.

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient aged over 18 years * Ovarian cancer patients with at least five tumor samples does not affect the diagnosis, based on other tumor masses * Surgery of any initial chemotherapy naive * Patient information and signed informed consent Exclusion Criteria: * A person deprived of liberty or under guardianship * Insufficient tumor samples of ovarian cancer.

Locations (1)

Centre François Baclesse

Caen, France

Outcomes

Primary Outcomes

rate of apoptotic cells

Time frame: 2 years

Data from ClinicalTrials.gov

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