Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis

Inclusion Criteria: * Female * Age 45-65 * BMI greater than or equal to 25 kg/m2, or a history of a knee joint injury or surgery, or knee symptoms (pain, aching, or stiffness) on most of the last 30 days, or knee osteoarthritis Exclusion Criteria: * Resistance training at any time in the last 3 months prior to study * Bilateral knee replacement * Lower limb amputation * Lower limb surgery in the last 6 months that affects walking ability or ability to exercise * Back, hip or knee problems that affect walking ability or ability to exercise * Unable to walk without a cane or walker * Inflammatory joint or muscle disease such as rheumatoid or psoriatic arthritis or polymyalgia rheumatica * Multiple sclerosis * Known neuropathy * Self-report of Diabetes * Currently being treated for cancer or having untreated cancer * Terminal illness (cannot be cured or adequately treated and there is a reasonable expectation of death in the near future) * Peripheral Vascular Disease * History of myocardial infarction or stroke in the last year * History of deep venous thrombosis * Chest pain during exercise or at rest * Use of supplemental oxygen * Inability to follow protocol (e.g. lack of ability to attend visits or understand instructions) * Staff concern for subject health (such as history of dizziness/faintness or current restrictions on activity) * Concurrent study participation (such as the MOST study) * Unable to attend more than 2 days within any 1 week or unable to attend 4 or more sessions during the study