Sevuparin/DF02 as an Adjunctive Therapy in Subjects Affected With Uncomplicated Falciparum Malaria

Inclusion Criteria: * Presence of acute uncomplicated P. falciparum malaria, confirmed by positive blood smear with asexual forms of a single species (P. falciparum) * Counts of asexual forms of P. falciparum: 10 000- 100 000/ul with or without gametocytaemia * Presence of fever defined as \> 38°C tympanic temperature or a history of fever within the last 24 hours Exclusion Criteria: * Mixed infection with other Plasmodium species * Any criteria of severe or complicated malaria as defined by the WHO, 2010 * Use of high doses aspirin (more than 100 mg/day) or dual anti-platelet therapy or use of heparin,Low Molecular Weight Heparin (LMWH) or warfarin * Presence of significant anemia as defined by Hb \<8 g/dL or Hct \< 25% * A platelet count \< 50,000/μL * Presence of febrile conditions caused by diseases other than malaria