A Study to Evaluate the Effect of ASP8597 in Adult Kidney Transplant Patients

Inclusion Criteria: * Subject is scheduled to receive a kidney transplant from a deceased donor meeting at least one of the following criteria: 1. Expanded Criteria Donor (ECD) * i Donor was \> 60 years of age, OR * ii. Donor was 50-59 years of age, inclusive, and met at least two of the following criteria: 1. Donor died of a cerebral bleed 2. Donor had a history of hypertension 3. Donor's terminal serum creatinine concentration was \> 1.5 mg/dL 2. Donation after Cardiac Death (DCD) - Donor was pronounced dead prior to procurement of the kidney 3. Standard Criteria Donor (SCD) * i. Donor with terminal serum creatinine \< 1.5 mg/dL where kidney is anticipated to have a minimum of 24 hours of cold ischemia prior to transplantation, OR * ii. Donor with terminal serum creatinine \> 1.5 mg/dL and any cold ischemic time up to exclusion limit * Female subject is not pregnant and agrees to use an acceptable form of contraception throughout study * Male subject agrees to use an adequate method of contraception and agrees to no sperm donation throughout the study Exclusion Criteria: * Female subject is pregnant or lactating * Donor kidney is anticipated to have more than 40 hours of cold ischemia time * Donor is \> 66 years of age * Donor meets both DCD and ECD criteria * Subject has previously received, or is receiving an organ transplant other than a kidney * Subject has a positive T or B cell crossmatch by the investigational site's standard method of determination. For recipients where only a flow cytometry crossmatch is performed and is positive in either T or B cell testing, recipients are excluded only if donor specific, anti-HLA antibody is detected by flow cytometry based, specific anti-HLA antibody testing * Subject has ABO blood type incompatibility with his/her organ donor * Recipient or donor is known by medical history to be seropositive for human immunodeficiency virus (HIV) * Subject has a known bleeding diathesis * Subject has a International Normalized Ratio (INR) \> 1.5 times upper limit of normal at Screening * Subject has a platelet count \< 100,000 platelets/µL at Screening * Subject used anti-platelet agents \[e.g., Plavix® (clopidogrel bisulfate), Brilinta® (ticagrelor)\] (with the exception of aspirin \< 100 mg/day for cardiovascular prophylaxis), anti-coagulants \[e.g., Pradaxa® (dabigatran), Xarelto® (rivaroxaban)\], anti-thrombotics, and/or blood-thinning agents within the 10 days prior to Screening; and/or subject is expected to require use of any of these agents during the first 15 days of the study period (with the exception of standard of care peri-operative administration of heparin for DVT prophylaxis) * Subject has an uncontrolled concomitant infection * Subject has a current malignancy or a history of any malignancy (within the past 5 years), except non-metastatic basal or squamous cell carcinoma of the skin that has been treated successfully * Subject currently is participating in an investigational drug study, or participated in an investigational drug study within the last 30 days) * Subject has a history of or is believed to have used an illicit drug(s) and/or abused alcohol within the last 3 months * Subject has an unstable psychiatric illness * Subject has previously received ASP8597 or participated in a study involving ASP8597