The Effects of Lycopene on High Risk Prostatic Tissue

Inclusion Criteria: * Male * Have a history of prostate biopsy indicating HGPIN without cancer within 2 years prior to registration. At least 4 weeks must have elapsed between the last biopsy and the biopsy used for baseline data. * Have an AUA symptom score \<=25 at time of registration. * Refrain from taking lycopene, selenium, vitamin E, or other antioxidant supplements within 1 month of randomization. Participants must agree to refrain from taking non-study dietary supplements while on study * Refrain from taking exogenous hormones, drugs affecting hormone metabolism, or specified non-prescription substances (e.g. saw palmetto, PC-Spes) taken to affect the prostate within 1 month of registration. Patients must also agree to refrain from taking the non-prescription substances while on study * Be willing to limit intake of lycopene-containing foods while on study * Have no prior cancer (except basal cell or squamous cell skin cancer) or complete remission for at least 5 years * Be ambulatory, capable of self-care and able to carry out light or sedentary work * Have a dietary fat intake of 23-48% of calories * Participant's physician recommends repeat biopsy 4-6 months after randomization Exclusion Criteria: * No repeat biopsy planned * Not willing to change diet * Have a diagnosis of prostate cancer