This research study is designed to investigate the effects of an online computer program, called OxIGen (Oxford Imagery Generation), on thinking style and mood in depression. The OxIGen program will be delivered online over four weeks and with follow-up at one, three and six months. This will inform potential future development of this computerized task into an online intervention to modify negative thinking styles in depression.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
150
Internet-based intervention with 12 sessions over 4 weeks
A control version of the OxIGen internet-based intervention (i.e. identical but with putative active components removed)
MRC Cognition and Brain Sciences Unit
Cambridge, Cambridgeshire, United Kingdom
Department of Psychiatry, University of Oxford
Oxford, Oxfordshire, United Kingdom
Change in score on Beck Depression Inventory - II
Time frame: Baseline and post-intervention (4 weeks)
Change in score on Quick Inventory of Depressive Symptoms - Self Report
Time frame: Baseline and post-intervention (4 weeks)
Change in State-Trait Anxiety Inventory (Trait scale)
Time frame: Baseline and Post-Intervention (4 weeks)
Change on Beck Anxiety Inventory
Time frame: Baseline and Post-Intervention (4 weeks)
Change on Scrambled Sentences Task
Time frame: Baseline and Post-Intervention (4 weeks)
Change on Life Orientation Test - Revised
Time frame: Baseline and Post-Intervention (4 weeks)
Change on Prospective Imagery Test
Time frame: Baseline and Post-Intervention (4 weeks)
Change on Behavioural Activation in Depression Scale
Time frame: Baseline and Post-Intervention (4 weeks)
Change in IAPT Toolkit
Includes the GAD-7, PHQ-9 and Work and Social Adjustment Scale
Time frame: Baseline and Post-Intervention (4 weeks)
Change on EuroQol-5D
Time frame: Baseline and Post-Intervention (4 weeks)
Change in Neuroticism
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Time frame: Baseline and Post-Intervention (4 weeks)
Change on Beck Depression Inventory - II
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on Quick Inventory of Depressive Symptoms - Self Report
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on State-Trait Anxiety Inventory (Trait scale)
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on Beck Anxiety Inventory
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on Life Orientation Test - Revised
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on Prospective Imagery Test
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on Behavioural Activation in Depression Scale
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on IAPT Toolkit
Includes GAD-7, PHQ-9, Work and Social Adjustment Scale
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on Euroqol-5D
Time frame: Baseline and Follow-Up (one month, three months, six months)
Change on Neuroticism
Time frame: Baseline and Follow-Up (one month, three months, six months)
Image Generation Task
Task adapted from Sharot et al. (2007, Nature)
Time frame: Post-Intervention (4 weeks)