The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation

Yonsei University40 enrolled

Overview

Biliary atresia (BA) is a perinatal disease of unclear etiology, characterized by inflammation and obliteration of intrahepatic and extrahepatic bile ducts, leading to cholestasis and cirrhosis. Kasai operation remains as the first line operative treatment in BA. In the previous studies, inhalation anesthetics might induce liver damage. The choice of inhalation anesthetic that minimally affects hepatic function is important. Therefore, the purpose of this study is to compare the postoperative recovery and hepatic function between desflurane and sevoflurane, two most frequently used inhalational anesthetics in patients undergoing Kasai operation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Kasai Operation Biliary Atresia

Interventions

40 patients are randomly allocated into two groups : desflurane group (n=20) and sevoflurane group (n=20). And anesthesia is maintained with desflurane (desflurane group) or sevoflurane (sevoflurane group).

sevoflurane anestheticsDRUG

Eligibility

Sex: ALLMax age: 1 Year

Medical Language ↔ Plain English

Inclusion Criteria: * patients with biliary atresia undergoing Kasai operation Exclusion Criteria: * patients with congenital anomalies at major organs

Locations (1)

Severance Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

Change in postoperative recovery

Complete blood count(CBC), prothrombin time(PT), activated partial thromboplastin time(APTT), aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP), albumin, total bilirubin, direct bilirubin, gamma-GTP, BUN, creatinine(Cr), electrolyte

Time frame: after operation, and on the 1st, 2nd, 3rd, 5th, 7th and 15th postoperative days.

Change in hepatic function

Time frame: after operation, and on the 1st, 2nd, 3rd, 5th, 7th and 15th postoperative days

Data from ClinicalTrials.gov

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