AZithromycin Against pLacebo in Exacerbations of Asthma

Inclusion criteria Patients meeting all of the following criteria will be considered for admission to the study: * Adults, either sex, ages 18-55 years or age 56 to 65 with \< 20 pack year smoking history or \>65 with \<5 pack year smoking history * Patients with a documented history of asthma for \>6 consecutive months, and * Patients presenting within 48 hours (of initial presentation to medical care) with an acute deterioration in asthma control (increased wheeze, dyspnea and/or cough and/or reduced PEF) and requiring a course of oral steroids * Patients with a PEF or FEV1 less than 80% of predicted normal or patient's best at presentation, at recruitment or in the time elapsed between presentation and recruitment * Patients must be able to complete diaries and quality of life questionnaires. * Patients must sign and date an informed consent prior to any study procedures. Exclusion criteria Patients presenting with any of the following will not be included in the study: * Patients with known prolongation of the QT interval, a history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias or uncompensated heart failure, patients on drugs known to prolong the QT interval and patients with ongoing proarrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and patients receiving Class IA (quinidine, procainamide) or Class III (dofetilide, aminodarone, sotalol) antiarrhythmic agents. * Smokers aged 56-65 with a \>20 pack year history, or aged \>65 with \>5 pack year history * Patients requiring immediate placement in ICU * Patients who used oral or systemic antibiotics within 28 days prior to enrolment * Patients with known impaired hepatic function (ALT/AST \> 2 ULN) * Patients with significant lung disease (including COPD) other than asthma * Patients with \> 20mg oral corticosteroid maintenance therapy * Patients requiring other antibiotic therapy * Patients who are receiving other medications or who have other disease conditions or infections that could interfere with the evaluation of drug efficacy or safety * Women who are breast-feeding or are pregnant, as demonstrated by a urine pregnancy test carried out before exposure to study medication or the start of any study procedure that could pose a risk to the foetus * Patients with suspected or known hypersensitivity to, or suspected serious adverse reaction to Azithromycin or any of the macrolide or ketolide class of antibiotics, erythromycin or to any excipients thereof * Patients who have received treatment with any other investigational drug within 1 month prior to study entry, or have such treatment planned for the study period during treatment and follow up phase * Patients with a concomitant condition (including clinically relevant cardiovascular, hepatic, neurologic, endocrine, or other major systemic disease) making implementation of the protocol or interpretation of the study results difficult * Patients with mental conditions rendering them unable to understand the nature, scope, and possible consequences of the study. * Patients unlikely to comply with the protocol, e.g., uncooperative attitude, inability to return for follow-up visits. * No subject will be allowed to enrol in this study more than once.