The purpose of this study is to quantify the systemic inflammatory and metabolic response of lean subjects and obese subjects to the ingestion of three caloric doses of a high-fat meal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
36
Three caloric doses of high-fat meal (500, 1000, 1500 kcal)
Agroscope Liebefeld-Posieux ALP Research Station
Bern, Canton of Bern, Switzerland
University Hospital Inselspital, Berne
Bern, Canton of Bern, Switzerland
Interleukin-6 (serum)
A statistically-significant increase in serum Interleukin-6 is expected at 4h compared to 0h
Time frame: 4h vs 0h
Glucose (serum)
Time frame: 0h, 1h, 2h, 4h, 6h
Triglyceride (serum)
Time frame: 0h, 1h, 2h, 4h, 6h
Insulin (serum)
Time frame: 0h, 1h, 2h, 4h, 6h
high sensitivity C-Reactive Protein
Time frame: 0h, 1h, 2h, 4h, 6h
HDL-cholesterol
Time frame: 0h, 1h, 2h, 4h, 6h
Total cholesterol
Time frame: 0h, 1h, 2h, 4h, 6h
Total cholesterol / HDL cholesterol
Time frame: 0h, 1h, 2h, 4h, 6h
Interleukin-6 (serum)
Time frame: 0h, 1h, 2h, 4h, 6h
Glucagon-like-protein-1 (serum)
Time frame: 0h, 1h 2h, 4h, 6h
Endotoxin (serum)
Time frame: 0h, 1h, 2h, 4h, 6h
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