Motor Performance in Parkinson's Disease After High Intensive Exercise or Deep Brain Stimulation

University of Copenhagen40 enrolled

Overview

The purpose of this study is (1) to provide quantitative information of the motor manifestations of Parkinson's disease and (2) to quantify the effect of high intensive antigravity locomotor exercise or Deep Brain Stimulation implantations in Parkinson's disease.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Parkinson's Disease

Interventions

High intensive antigravity locomotor exerciseOTHER

High intensive antigravity locomotor exercise, 3 sessions/week, for 8 weeks.

Deep Brain StimulationPROCEDURE

Deep Brain Stimulation implantation

Eligibility

Sex: MALEMin age: 50 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria (exercise arm): * Idiopathic Parkinson's disease * A stable condition the last 6 months * Hoehn and Yahr 2 - 3 Inclusion Criteria (Deep Brain Stimulation arm): * Patients referred to Deep Brain Stimulation Exclusion Criteria: * Cardiovascular disease * Conditions that contraindicate physical exercise or the examination

Locations (1)

Hvidovre University Hospital

Hvidovre, Denmark

Outcomes

Primary Outcomes

Change in Isometric Tremor Approximate Entropy

Approximate Entropy is a metric. When used to quantify isometric tremor irregularity, information of dominant/pathological CNS oscillators can be obtained.

Time frame: Change from baseline up to 16 weeks

Data from ClinicalTrials.gov

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