Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)

INCLUSION CRITERIA: The following are requirements for inclusion in the study: * Male or female patient, at least 18 years of age, who is a candidate for DMEK due to corneal endothelial dysfunction or who has undergone DMEK within the last 7 weeks * Patient is able and willing to administer eye drops. * Patient is able to comprehend and has signed the Informed Consent form. * Patient is likely to complete the entire one-year course of the study. * Patient has best corrected visual acuity (BCVA) of at least 20/200 in the fellow eye. * Corneal neovascularization will not be judged as an exclusion criteria for the study EXCLUSION CRITERIA: The following are exclusion criteria for patients in this study: * A patient with a previous failed graft in the study eye with a history of a prior rejection episode * A patient exhibiting any intraocular inflammation * A patient with a known sensitivity to any of the ingredients in the study medications * A patient who has a condition (i.e., UNCONTROLLED systemic disease) or is in a situation which in the investigator's opinion may put the patient at significant risk, may confound the study results, or may interfere significantly with the patient's participation in the study * A patient with abnormal eyelid function * A patient that is exhibiting active corneal ulceration, keratitis, or conjunctivitis, or who has a history of herpetic keratitis * A patient with the presence of any ocular disease that would interfere with the evaluation of the study treatment * A patient with a history of non-compliance with using prescribed medication * A patient who is concurrently involved in or participated in another clinical trial within 30 days prior to enrollment in this study.