24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice

Inclusion Criteria: * Patient has exfoliation syndrome with ocular hypertension, or exfoliative glaucoma and is older than 29 years * Patient is newly diagnosed, or currently untreated and exhibits untreated morning IOP (2 separate IOP readings at 10:00)greater than 29 mm Hg in the study eye * Study patients should have mild to moderate exfoliative glaucoma (VF loss \<12 dB; cupping 0.8 or less) * Patient with exfoliation syndrome should fulfill the IOP criterion (IOP \> 29 mm Hg at 10:00) * Patient deemed by investigator to require significant IOP reduction to obtain desired target IOP * Patient agrees to be treated for at least 3 months with latanoprost and bimatoprost/timolol fixed combination drops dosed in the evening * In study eye distance best corrected Snelen visual acuity greater than 1/10 Exclusion Criteria: * Contraindications to therapy with latanoprost, bimatoprost, or β-blockers * History of non-adherence or previously recorded evidence of lack of response (\<10% morning IOP reduction) to any antiglaucoma medication * Patient can not understand the instructions and adhere to medications * Patient is a female of childbearing potential or lactating mother * Past history of trauma, inflammation, surgery, past use of steroids (within 2 months), severe dry eyes and use of contact lenses * Signs of ocular infection, except blepharitis, or corneal abnormality that may affect IOP measurements * The other eye can not receive the same therapy, or remain without medical therapy * Closed angles