A Study Of The Effects Of OC000459 In Subjects Known To Suffer From Grass Pollen Induced Allergic Rhinitis

Inclusion Criteria: * Males aged 18 to 50 years with a history of symptoms of grass pollen related allergic rhinitis within the previous two years. * Subjects must be free from significant cardiac, pulmonary, gastrointestinal, hepatic, renal, haematological, neurological and psychiatric disease as determined by history, physical examination and screening investigations. * FEV1 within normal limits (≥90% of predicted). * Atopy defined by a positive cutaneous response to mixed grass pollen within the last 12 months or at screening. * Asymptomatic at screening * Non smokers for at least the past 12 months Exclusion Criteria: * Medical conditions likely to affect the outcome of the study. * Nasal conditions likely to affect the outcome of the study, i.e. nasal septal perforations, nasal polyps, sinus disease, chronic nasal obstruction, or other nasal diseases. * Presence of any respiratory disease other than a history of mild stable asthma not requiring treatment and associated with normal lung function * Immunotherapy treatment course including inhaled or local corticosteroids in the past 28 days.