Collection and Study of Cerebrospinal Fluid in Patients With Hunter Syndrome

Inclusion Criteria: * The patient is male and has a documented diagnosis of Hunter syndrome (MPSII). * The adult patient has completed a cognitive assessment at screening/baseline or within the previous 3 months and has been determined to have an intelligence quotient (IQ) ≥78. Note: cognitive evaluation of pediatric patients is not required. * The adult patient or the adult patient's legally authorized representative(s) has voluntarily signed an Institutional Review Board/Independent Ethics Committee-approved informed consent form after all relevant aspects of the study have been explained and discussed. * The pediatric patient must be scheduled to undergo a non-study related lumbar puncture or other medical or diagnostic procedure that requires the administration of general anesthesia. The pediatric patient's parent(s) or legally authorized representative(s) must have provided written informed consent (with patient assent as relevant), after all relevant aspects of the study have been explained and discussed, to allow CSF sample collection for this study in conjunction with performance of the non-study related procedure requiring general anesthesia. Exclusion Criteria: * The patient has a history of complications from a previous lumbar puncture(s) or technical challenges in conducting lumbar puncture. * The patient has received a hematopoietic stem cell transplant. * The patient has taken aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), or other over-the-counter or prescription medications that could affect blood clot formation within the 7 days prior to lumbar puncture, or has ingested such medications within 7 days prior to any study-related procedure in which a change in potential blood clot formation would be deleterious. * The patient is currently receiving treatment with intrathecal idursulfase-IT. * The patient is currently enrolled in an interventional clinical trial. * The patient has participated in a clinical trial of any investigational drug, including idursulfase-IT, or device within the 30 days prior to study entry.