Predictors of Postoperative Pain

American University of Beirut Medical Center60 enrolled

Overview

The purpose of the study is to prove that pain scores generated from painful stimuli applied preoperatively may help identify the inter-individual variability in pain perception.

Psychological factors and experimental pain models such as as electrical, pressure, heat, or cold stimuli have been identified as predictors of pain intensity and opioid consumption postoperatively. This study will investigate, in addition to the factors described above, the ability of pain scores generated from painful stimuli postoperatively in predicting postoperative pain.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Postoperative Pain

Interventions

Thermal Sensory Analyzer (Senselab)DEVICE

Thermal stimuli will be administered to the ventral surface of the dominant forearm and then to the lower abdomen (surgical site)using the Thermal Sensory Analyser. Each thermal testing trial will be separated by approximately 2 min and at a separate site. To measure the thermal pain threshold temperature, The thermode will be applied to the ventral surface of the dominant forearm and the temperature will be increased at 1°C/s from 35 to 50°C. To measure the Suprathreshold Thermal Pain Intensity and unpleasantness, Stimulus responses for noxious heat stimuli will be performed by applying phasic heat stimuli at 8 different temperatures (35, 43, 44, 45, 46, 47, 48, and 49°C).

Eligibility

Sex: FEMALEMin age: 35 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing abdominal hysterectomy through a pfannenstiel incision * American Society of Anesthesiologists (ASA)Class I-III Exclusion Criteria: * Patients with a history of psychiatric disease * Diabetic or alcoholic patients who may have impaired sensation due peripheral neuropathies * chronic opioid or nonsteroidal antiinflammatory drug use * chronic pain conditions

Locations (2)

American Unversity of Beirut Medical Center

Beirut, Lebanon

AUBMC

Beirut, Lebanon

Outcomes

Primary Outcomes

pain scores from IV insertion

Time frame: 15 minutes prior to induction