The aim of the study is to prove that acupuncture applied before and after embryo transfer is able to increase pregnancy rates by means of reducing stress and improving endometrial vascularization in women receiving in vitro Fertilization (IVF) treatments.
Around 75% of all in vitro fertilization (IVF) treatments fail in providing a healthy baby at home. Most of the women undergoing those techniques suffer in some extent anxiety, depression and stress. Stress make IVF results worse and it has been prove by correlating cortisol, adrenaline and noradrenaline levels with failed cycles. Acupuncture has proved its ability to reduce stress levels. Moreover, Acupuncture has prove to have an effect inhibitory on the sympathetic system and this capacity improves vascularization in uterus and ovaries. Available literature concerning these two issues is not conclusive because of studies design. Acupuncture´s biological mechanism on controlled ovarian stimulation and embryo transfer has not been completely described; if it really has one. Published studies show very different designs and inconclusive/contradictory results can be withdrawn making very difficult to take the clinical decision of recommending acupuncture or not to in vitro fertilization (IVF) patients. If acupuncture really enhance pregnancy rates in IVF cycles still unanswered given that no randomized three arms study comparing no intervention to sham acupuncture to acupuncture has been published.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
286
Bed rest during 25 minutes on day 1, 4 and 6 of ovarian stimulation, before and after embryo transfer
Sham acupuncture during 25 minutes on day 1, 4 and 6 of ovarian stimulation, before and after embryo transfer
Acupuncture during 25 minutes on day 1, 4 and 6 of ovarian stimulation, before and after embryo transfer
Human Reproduction Unit of the University and Politechnic Hospital La Fe.
Valencia, Spain
Pregnancy rate
Heart beating in intrauterus embryo
Time frame: 14 days after embryo transfer
Rating preconceived ideas about acupuncture
Rating preconceived ideas about acupuncture
Time frame: From 24 hours (h) to 14 days after embryo transfer
Determination of serum prolactin and 24h urine cortisol.
Determination of serum prolactin and 24h urine cortisol to measure stress levels on the day of embryo transfer.
Time frame: The day of embryo transfer (+14 days post-cycle start)).
Endometrial vascularization study
Endometrial vascularization study on the day of embryo transfer, 2 days before and after it
Time frame: The day of embryo transfer (+14 days after cycle start) and 2 days before and after it.
Analysis of the results of assisted reproductive cycle
Analysis of the results of assisted reproductive cycle on levels of beta human chorionic gonadotropin (BhCG) +14 days post-transfer, evidence of intrauterine gestational sac with heartbeat and embryo live birth at home
Time frame: After 14 days post-transfer (28 days after cycle star)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.