The aim of this single centre study is to measure maternal CD4+ t-cells in HiV exposed Newborns after spontaneous birth in comparison to cesarean section. This may have an influence on the risk of vertical HiV transmission.
At birth maternal CD4+ t-cells from umbilical cord blood and placenta blood are measured by microchimerism-analysis. After 6 weeks the maternal CD4+ t-cells are measured in the blood of the babies blood. Additionally we look for HiV in maternal CD4+ t-cells.
Study Type
OBSERVATIONAL
Enrollment
54
Clinic of the Johann Wolfgang-Goethe Univeristy
Frankfurt am Main, Hesse, Germany
Maternal CD4+ t-cells in HiV exposed Newborns
The maternal CD4+ t-cells are measured by microchimersimanalysis
Time frame: Six weeks after date of birth
HiV transmission rate
Measurement of HiV PCR at the age of 6 month after birth
Time frame: 6 month after birth
Analysis of HiV in maternal CD4+ t-cells
HiV-PCR analysis from maternal CD4+ cells
Time frame: 2 month after delivery
Measurement of maternal CD8+ t-cells in the Newborn
Measurement of maternal CD8+ t-cells by microchimerismanalysis
Time frame: 6 weeks
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