Evaluation of the MANOS Carpal Tunnel Release System in Patients With Carpal Tunnel Syndrome

Inclusion Criteria: * Patient is scheduled to undergo carpal tunnel release surgery. * Patient has chronic Carpal Tunnel Syndrome with persistent symptoms despite non-operative treatment, or refusal of non-operative treatment, with one or more of the following: splinting, NSAIDs or corticosteroid injections. * Carpal Tunnel Syndrome must be confirmed by positive results of Electromyography (EMG) and Nerve Conduction Velocity (NCV) tests. * Patient is a male or non-pregnant, non-lactating female. * Patient is 18-75 years of age, inclusive. * Female patients of child-bearing potential, including those who have had a tubal ligation, but excluding those who have not experienced a menstrual period for at least two years, must have a negative urine pregnancy test at Screening. * Patient must voluntarily provide written, informed consent. Exclusion Criteria: * Patient has a prior or current musculoskeletal or neurologic condition that limits strength, motion, or sensation in the affected hand. * Patient has a medical condition that precludes the use of anesthetic required for surgery. * Patient has an ipsilateral injury or other conditions affecting hand function. * Patient has acute CTS resulting from an injury (e.g., fracture). * Patient has had previous CTR surgery on the affected hand. * Patient has psychiatric history, head injury or any other condition which, in the Investigator's opinion, would prevent patient from complying with post-operative hand therapy or follow-up visits.