During repair of a congenital heart defect the child is exposed to myocardial hypoxia. Recent studies have suggested that the paediatric myocardium is more sensitive to hypoxia and cardioplegic arrest than the adult. The protective effect of halogenated agents on ischaemia and reperfusion injury has been investigated widely in adults. The investigators hypothesis that sevoflurane applied during cardiopulmonary bypass might afford better myocardial protection during paediatric cardiac surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
Sevoflurane will be given at a concentration of 2% through oxygenator during CPB
Patients will receive only oxygen and air through oxygenator
Department of Cardiovascular Surgery, Xijing Hospital
Xi'an, Shaanxi, China
RECRUITINGall cause mortality
All cause mortality after the cardaic surgery, patients will be followed up for 30 days
Time frame: within the first 30 days (plus or minus 3 days) after surgery
serum cTnI concentrations
serial serum cTnI concentrations will be determined to whether sevoflurane application during CPB will decrease the cTnI release after operation.
Time frame: 48 h after the surgery
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