GLP-1 Receptors in Normal Skin and Skin From Patients With Psoriasis

4.3 Inclusion Criteria * Caucasians above 18 years of age * Plaque psoriasis * PASI score \>10 * No treatment or stable treatment of psoriasis during at least 3 months before inclusion * Steady weight through 3 months with a body mass index (BMI) above 27 kg/m2 * Normal blood pressure * Spiral or hormonal birth control for fertile women during the entire treatment period and at least 3 days after the end of the treatment period (\~5 times the plasma half-life) 4.4 Exclusion Criteria * Psoriasis arthritis * Fasting plasma glucose \> 7.5 mmol/L or HbA1c \> 7.5% * Type 1 diabetes * Treatment for type 2 diabetes with GLP-1-based medicine (DDP-4-inhibitors or GLP-1-receptor-agonists) * Heart failure, NYHA class III-IV * Uraemia, end-stage renal disease, or any other cause of impaired renal function with s-creatinine \>150 µM and/or albuminuria * Liver disease (alanine amino transferase (ALAT) and/or aspartate amino transferase (ASAT) \>2 x upper normal serum levels) * Anaemia * Acute or chronic pancreatitis * Struma or thyroid cancer * Pregnancy or breast feeding * Inability to complete the study