Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity

N/ACompletedNCT01452048

University of Michigan38 enrolled

Overview

The investigators specific aim is to compare the relationship between systemic fatty acid availability and insulin sensitivity in a relatively homogenous population of obese adults. The investigators anticipate 1) greater systemic fatty acid availability will be associated with lower insulin sensitivity and 2) greater systemic fatty acid availability will be associated with greater accumulation of fatty acid intermediates and pro-inflammatory markers.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Body mass index \[BMI\]: 35-45 kg/m2; All women must be pre-menopausal; Non-exerciser (no regularly planned exercise/physical activity) Exclusion Criteria: * Weight instability ≥ ±5 lbs. in past month; medications known to affect lipid and/or glucose metabolism; Pregnancy or actively breast feeding

Locations (1)

Michigan Clincal Research Unit

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Insulin Sensitivity

A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity

Time frame: 2-3 hours

Secondary Outcomes

Resting Metabolic Rate

Time frame: 20-30 min

Data from ClinicalTrials.gov

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