The main purposes of this study are: * to describe the prevalence and degree of reduced left ventricular function and hypertrophy in patients with peripheral arterial disease in comparison to controls from the general population, * to evaluate factors of importance to left ventricular dysfunction and hypertrophy in patients with peripheral arterial disease, and * to assess the impact of cardiac function and left ventricular hypertrophy on long-term prognosis in patients with peripheral artery disease.
Left ventricular dysfunction is often a consequence of coronary heart disease (CHD). CHD is prevalent among patients with peripheral artery disease. However, there is limited data regarding left ventricular morphology and function in those patients. In the cross-sectional part of this study we will describe the prevalence of reduced cardiac function and left ventricular hypertrophy in a cohort of patients with peripheral artery disease. The patient outcomes will be compared to control subjects randomly selected from the general population in a case-control design. Further, clinical and genetic determinants of cardiac dysfunction in the patient cohort will be identified. In the longitudinal part of the study, the impact of cardiac function and morphology on cardiovascular mortality and morbidity will be evaluated in the cohort.
Study Type
OBSERVATIONAL
Enrollment
457
Center of Clinical Research, Uppsala university, Central Hospital
Västerås, Sweden
Left ventricular ejection fraction (cross-sectional outcome measure)
LVEF obtained by echocardiographic biplane disk summation method. In the cross-sectional study, the mean value of LVEF and the prevalence of reduced LVEF (LVEF \< 50%) in the patient group will be compared to the control group.
Time frame: baseline
Cardiovascular events (longitudinal outcome measure)
Cardiovascular events obtained from the Swedish National Causes of Death register and the Swedish National In-patient register. The registers are linked to the patients by the unique personal identification number assigned to each swedish resident.
Time frame: 5-10 years
Left ventricular mass (cross-sectional outcome measure)
Left ventricular mass obtained by 2-dimensional echocardiography according to the American Society of Echocardiography.
Time frame: baseline
Wall motion score index (WMSI)
Left ventricular wall motion score according to the American Society of Echocardiopgraphy.
Time frame: baseline
Echocardiographic left ventricular filling variables
Echocardiographic variables for evaluation of left ventricular diastolic function (e.g. E/A- and E/e'-ratios).
Time frame: baseline
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