Diode Laser Treatment of Onychomycosis

Inclusion Criteria: * Confirmed subungual onychomycosis in a great toe that does not extend to the eponychium * Fitzpatrick Skin Type I-IV * Written and verbal informed consent * Able to comply with study instructions and to return to the clinic for required visits * Agrees to refrain from other active topical, laser or light-based treatment to the great toes * Agrees to the use of Naftin Gel between the toes to prevent/control tinea pedis Exclusion Criteria: * Pregnancy, breastfeeding or planning to become pregnant * History of cutaneous photosensitivity, porphyria and hypersensitivity to porphyrins or photodermatoses * Any skin pathology or condition that could interfere with the evaluation or that requires the use of interfering topical or systemic therapy * Coagulation disorder or current use of anti-coagulation medication (including aspirin use of greater than 81 mg per day) * Any condition which, in the investigator's opinion, would make it unsafe for the subject to participate * Enrolled in an investigational drug or device trial, or has been treated with an investigational device or received an investigational drug within 30 days * Oral Lamisil within 1 year, Sporanox or over-the-counter topicals within 1 month, or other prescription anti-fungal medications or topicals within 6 months * Evidence of diabetic neuropathy or peripheral vascular disease related to diabetes, or a loss of protective sensation in the affected foot * Psoriasis, lichen planus, infection involving the lunula, prior surgical treatment of the affected great toe within 1 year, or a history of trauma to the affected great toe * Immunocompromised status, or with existing (or history of) cancer/skin malignancy * Distal nail thickness of greater than 2mm in the affected great toenail