From Uncomplicated Alcoholism to Korsakoff's Syndrome

Inclusion Criteria: * Completed at least 8 years of education (primary school equivalent) * Age-normal corrected hearing and visual acuity Exclusion Criteria: * documented loss of consciousness of over 30 minutes, documented compound skull fracture, or clear neurological sequelae of head trauma * history of medical or neurological illness or trauma potentially affecting the CNS, e.g., stroke, multiple sclerosis, epilepsy, psychosurgery, insulin coma. * active tuberculosis or history of or any malignancy requiring chemotherapy * history of schizophrenia or bipolar disorder * metal implantation (e.g., pacemakers) or other factors that preclude MRI scanning for subjects selected for the neuroimaging examination * meet DSM-IV criteria for current (past 3 months) other Substance Abuse * met DSM-IV criteria for other Substance Dependence * Have used other substances more than 5 times in the past month