The objective of this study is to investigate the effects of physical training in patients with type 2 diabetes during treatment with the GLP-1 receptor agonist liraglutide (Victoza®) in a 16-weeks double-blinded, randomized placebo-controlled clinical trial. Hypothesis: Physical training leads to better metabolic control in type 2 diabetic patients when training is combined with liraglutide (Victoza®) treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
Department of Internal Medicine, Gentofte Hospital
Hellerup, Denmark
HbA1c
Change in HbA1c from baseline to 16 weeks. Glycated haemoglobin (HbA1c) is a form of haemoglobin which is measured primarily to identify the average plasma glucose concentration over prolonged periods of time (12 weeks).
Time frame: 16 weeks
Maximal oxygen uptake (VO2peak)
Changes in VO2peak from baseline to 16 weeks
Time frame: 16 weeks
Body weight
Changes in body weight from baseline to 16 weeks evaluated by a full body DEXA scan
Time frame: 16 weeks
Blood pressure
Changes in blood pressure from baseline to 16 weeks
Time frame: 16 weeks
Glycaemic control
Changes in overall glycaemic control parameters, insulin sensitivity and beta cell function evaluated by The Homeostasis Model Assessment (HOMA) and incretin hormones response
Time frame: 16 weeks
Meal test
The changes in the postprandial response of incretin hormones, insulin and glucose, glucagon and the microvascular blood flow will be evaluated. Changes in blood leves of triglycerides and cholesterol.
Time frame: 16 weeks
Myocardial echocardiography
Time frame: 16 weeks
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