Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing

Inclusion Criteria: * successful PCI * 600 mg clopidogrel pretreatment * clopidogrel low response assessed with electrode aggregometry (\>= 486 AU\*min) * written informed consent Exclusion Criteria: * Contraindications or allergies against study drugs * Anemia * Any surgery \< 6 weeks * Increased bleeding risk * Oral anticoagulation * platelet count \< 100.000/µl * Prior history of stroke or pathologic intracranial findings * GPIIb/IIIa antagonists \< 10 days or periprocedural * Age \> 80 years, \< 18 years * Body weight \< 60 kg * Cardiogenic shock * Increased risk of bradycardia * Moderate liver disease * Kidney dialysis * Intake of CYP 3A4 inhibitors * Pregnancy or lactation * Missing pregnancy test for women capable of bearing children