Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients

University Hospital, Basel, Switzerland300 enrolled

Overview

Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging. Osmotically inadequate secretion of antidiuretic hormone (ADH) is the predominant mechanism in most dysnatremic disorders. ADH measurement is cumbersome. It is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of ADH. Objective: To evaluate the additional value of copeptin to improve a currently used algorithm in the differential diagnosis of (A) severe hypoosmolar hypo- and (B) severe hypernatremia. Design: Prospective observational study.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Hyponatremia Hypernatremia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 110 Years

Medical Language ↔ Plain English

Inclusion Criteria: * hyponatremia \<125 or hypernatremia \>155 mmol/L Exclusion Criteria: * no informed consent

Locations (2)

Mirjam Christ-Crain

Basel, Basel, Switzerland

Outcomes

Primary Outcomes

diagnostic accuracy of copeptin within hospital stay

diagnostic accuracy will be determined by receiver operated curve (ROC) analysis. The study is powered to detect a difference of copeptin levels between patients with partial central diabetes insipidus (DI) and patients with primary polydipsia.

Time frame: participants will be followed for up to 1 year