Study of Mantle Cell Lymphoma Treatment by RiBVD

Inclusion Criteria: * mantle cell Lymphoma CD20 positive * Untreated patients * 65 ans years old patients or 18 to 65 years old patients who can't or refuse receive conditioning regimen followed by autograft. * Stages Ann Arbor II, III or IV, * ECOG performance status of 0, 1 or 2 * Without history of neoplasm, except in situ cervix carcinoma and cutaneous basal cell epithelioma, or in complete remission since 3 years, * Without drug contraindication used in the schema (Rituximab, benda-mustine, Velcade, Dexamethasone), * Without heart insufficiency or stabilized, * With the following biological values limits except if pathological values are due to Medullary invading or hypersplenism, hepatic involvement) :PNN more than 1 G/L, Platelets more than 50 G/L,Transaminases (SGOT and SGPT) and alkalin phosphatases alcalines less than 4 x normal,Bilirubin less than 3 x N,- Clearance creatinemia more than 20 mL/min * Hepatitis B negative serology unless the seropositivity is clearly linked to a vaccination. * Can be regularly followed * Who signed the informed consent, * Affiliated to a national insurance or such a same scheme . Exclusion Criteria: * Other type of lymphoma than mantle cell lymphoma according to OMS 2008 classification * Patients in relapse, except those in relapse due to localized stade who only received locoregional irradiation or splenectomized, * Central nervous system localization in particular meninge, * Drug used in the schema contraindication Rituximab , Bendamustine , Velcade® or Dexamethasone * Non stable diabetes, * HIV positive or active hepatitis C or B * ECOG performance status equal or more than 3 * Peripheral neuropathy, whatever its origin, rated more than 2 from NCI * Non stabilized heart insufficiency, * Patient who can't receive hyperhydration in order to treat tumoral lysis syndrome or in prophylaxis, * Patient who can't, whatever the reason, be regularly followed, * Major patient who are on legal protection, or can't give their consent * Patient who has not signed the informed consent