Immunogenicity and Reactogenicity of DTPa-HBV-IPV/Hib, Compared to DTPa-HBV-IPV and Hib Administered Separately

Inclusion Criteria: * A male or female 3 months of age at the time of the first vaccination. * Free of obvious health problems as established by medical history and clinical examination before entering into the study. * Written informed consent obtained from the parents or guardians of the subject after they have been advised of the risks and benefits of the study in a language which they clearly understood, and before performance of any study procedure. Exclusion Criteria: The following criteria should be checked at the time of study entry. If any apply at the time of study entry, the subject must not be included in the study: * Use of any investigational or non-registered drug or vaccine other than the study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned use during the study period. * Administration of chronic immunosuppressants or other immune-modifying drugs within three months before vaccination. * Administration of a vaccine not foreseen by the study within 30 days before each dose of the study vaccines and ending 30 days after. * Previous vaccination against diphtheria, tetanus, pertussis, hepatitis B, polio and/or Hib disease. * History of /or intercurrent diphtheria, tetanus, pertussis, hepatitis B, polio and/or Hib disease or infection. * Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection. * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine, including allergic reactions to neomycin and polymyxin B. * Major congenital defects or serious chronic illness. * History of seizures or of any neurological disease at study entry. * Administration of immunoglobulins and/or any blood products since birth, or planned administration during the study period. * Acute disease at time of enrolment