To evaluate the kinetics of intestinal absorption of vitamin E water-soluble form from the classical lipid-soluble form in a population of patients with intestinal malabsorption (hypocholesterolemias family by retention of chylomicrons).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
14
Administration of a daily dose of vitamin E for 4 months:50 IU/kg
Administration of a daily dose of vitamin E for 4 months:50 IU/kg
Administration of a single dose of vitamin E (Vitamin E water-soluble then Vitamin E conventional fat-soluble form)
Hopital Femme Mere Enfant-Hospices Civils de Lyon
Bron, France
Measurement the area under the curve of absorption of vitamin E according to its dosage form (fat-soluble versus water-soluble) in the beginning of each treatment period. versus water-soluble) in the beginning of each treatment period.
Time frame: 12 months
Measurement of serum (membranes erythrocytic) of vitamin E at the beginning and after each treatment.
Measurement of serum (membranes erythrocytic) of vitamin E at the beginning and after each treatment. Search for a correlation between the rates in adipose tissue and those in the membrane of erythrocytes.
Time frame: 12 months
Measurement of tissue (subcutaneous adipose tissue) of vitamin E at the beginning and after each treatment.
Measurement of tissue (subcutaneous adipose tissue) of vitamin E at the beginning and after each treatment. Search for a correlation between the rates in adipose tissue and those in the membrane of erythrocytes.
Time frame: 12 months
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