Quetiapine Compared With Placebo in the Management of Fibromyalgia

Inclusion Criteria: * Age 18 to 60, inclusive * Females of childbearing potential using reliable method of contraception AND negative urine pregnancy test. * Widespread pain present for at least 3 months * Widespread encompassing both sides of the body, as well as above and below the waist * Pain in at least 11 of 18 tender points as determined by a physician Exclusion Criteria : * Pregnant or breastfeeding * Use of any of the following in the 14 days prior to enrollment: ketoconazole, itraconazole, fluconazole, erythromycin, clarithromycin, troleandomycin, indinavir, nelfinavir, ritonavir, fluvoxamine, saquinavir phenytoin, carbamazepine, barbiturates, rifampin, St. John's Wort, and glucocorticoids. * Administration of a depot antipsychotic injection within one dosing interval (for the depot) before enrollment * Substance or alcohol dependence at enrollment (except in full or recovery, and except nicotine or caffeine dependence) * Abuse of any of the following within 4 weeks of enrollment: opiates, amphetamine, barbiturate, cocaine, cannabis, or hallucinogen * Medical conditions that would affect study treatment * Unstable or inadequately treated medical illness (e.g. diabetes, angina pectoris, hypertension) as judged by investigator * Involvement in the planning and conduct of the study * Previous enrollment or randomization of treatment in the present study * Participation in another drug trial within 4 weeks prior to enrollment in this study or longer * Admitted to hospital for Diabetes Mellitus (DM) related illness in past 12 weeks * Not under physician's care for DM * Physician responsible for your DM care has indicated you DM is uncontrolled * Physician responsible for your DM care has not approved your participation in the study * Have not been on the same dose of DM medicine and/or diet for the 4 weeks prior to starting the study * For thiazolidinediones (glitazones) this period should not be less than 8 weeks * Taking insulin whose daily does on one occasion in the past 4 weeks has been more than 10% above or below your mean dose in the preceding 4 weeks * A low white blood cell count