Understanding Immunity Persistence After Adolescent MenC Vaccination

University of Oxford134 enrolled

Overview

The main purpose of this study is to evaluate the duration of immunity after a booster dose of a MenC-CRM vaccine given to adolescents between 13 and 15 years of age. Does seroprotection persist beyond teenage years and into the early twenties? This is the age group which is most likely to carry the organism and to transmit it to other members of the population. If a booster dose of MenC vaccine given to adolescents does produce protective levels of antibody which persist into early adulthood, this would strengthen the case for such a booster to be added to the UK routine immunisation schedule, to reduce the risk of a resurgence of the disease in the future.

Study Type

OBSERVATIONAL

Enrollment

134

Conditions

Antibody Persistance After Booster Dose of Men C Vaccine

Interventions

Venepuncture and blood sample collection.OTHER

Venepuncture and blood sample collection.

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Participants who completed clinical study M14P2E1 * Participant who are willing to participate and who would be expected to comply with the requirements of the protocol * Participants who have given informed consent for participation in the study Exclusion Criteria: * History of invasive meningococcal C disease (or any case of invasive meningococcal disease where the serotype was unknown) * Confirmed or suspected immunosuppressive or immunodeficient conditions, including human immunodeficiency virus (HIV) infection * Severe blood clotting disorders

Outcomes

Primary Outcomes

Percentage of participants with rSBA titre ≥1:8 (correlate of protection).

Time frame: 4 months

Secondary Outcomes

Geometric mean titre (GMT) rSBA.