Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy and Distal Pancreatic Resection

Tampere University Hospital

Overview

The purpose of this randomized, placebo-controlled trial is to investigate whether postoperative pancreatitis and other immediate complications after pancreaticoduodenectomy or distal pancreatic resection may be reduced with cortisone treatment. Treatment is administered to high risk patients (defined by high amount of acinar cells in the cut edge of pancreas).

Study Type

INTERVENTIONAL

Conditions

Postoperative Complications Postoperative Pancreatitis

Interventions

HydrocortisoneDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pancreaticoduodenectomy and distal pancreatectomy patients in Tampere University Hospital Exclusion Criteria: * Patients with an ongoing cortisone treatment * Cefuroxime allergy * Chronic pancreatitis

Locations (1)

Tampere University Hospital

Tampere, Finland

Outcomes

Primary Outcomes

Postoperative overall complications of pancreatic resection

e.g. Postoperative pancreatic fistula, delayed gastric emptying, postpancreatectomy hemorrhage, biliary fistula, wound infection, postoperative pancreatitis.

Time frame: within the first 30 days after surgery

Data from ClinicalTrials.gov

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