Heme Arginate in Functional Magnetic Resonance Imaging (fMRI)

Inclusion Criteria: * Signed informed consent * Men aged between 18 and 46 years (inclusive) * Nonsmoker for more than 3 months * Body mass index between 18 and 27 kg/m2 * Normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant * Negative results from urine drug screen if performed * Ability to communicate well with the investigator in the local language and to understand and comply with the requirements of the study Exclusion Criteria: * Known hypersensitivity to the study drug or any excipients of the drug formulation * Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * Treatment with another investigational drug within 3 weeks prior to screening * History or clinical evidence of any disease and/or existence of any surgical or medical condition, which might interfere with the absorption, distribution, metabolism or excretion of the study drug * Evidence of hypertension, pathologic hyperglycemia, hyperlipidemia * Treatment in the previous 3 weeks with any drug including over-the-counter drugs (including herbal medicines such as St John's Wort) * Symptoms of a clinically relevant illness in the 2 weeks before the first study day * Blood donation during the previous 3 weeks * Any metallic, electric, electronic or magnetic device or object not removable * Claustrophobia